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GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]

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13,14,32 These challenges could not be resolved by increasing the administered dose, since this can lead to a parallel increase in the incidence of side effects

Akkermansia muciniphila, a probiotic strain, is gaining appeal for positively impacting metabolic function

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8-12 Specifically, the addition of a GLP-1 RA may also confer the added benefit of slowing the progression of albuminuria