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Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, CriglerNajjar syndrome, LuceyDriscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (DubinJohnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome)

for example, weight loss associated with the use of GLP-1 RAs in people without cancer may be associated with the prevention of obesity-related cancers

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Since being deemed a public health emergency in 2017, opioids are responsible for 72% of drug overdose deaths in the United States, according to the N...