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Ethical approval This study was approved by the Mass General Brigham Institutional Review Board and was conducted in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethics standards

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First, we observed an increased number of activated PSCs in L-arginine-induced AP, which is consistent with findings from a previous report, 63, 64 which demonstrated increased -SMA expression (a marker for activated PSCs) coincided with TGF- 1 activation in this model
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