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Preclinical trials demonstrate that this co-agonist improves glucose tolerance, indicating that the GLP-1 activity can successfully buffer the hyperglycaemic potential of GcgR agonism

Based on the information we have so far, retatrutide may lead to more weight loss than semaglutide (Wegovy) or tirzepatide (Mounjaro)

In any medication that reduces appetite, nutritional adequacy becomes a concern

[5] [6] The frequency appears comparable to other GLP-1 agonists, though longer-term post-marketing data are still accumulating

Patient is a 28-year-old woman with BMI 26 and PCOS

Amylin is co-secreted with insulin from beta cells to regulate appetite, gastric emptying, and postprandial glucagon secretion