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The paradigm shift from glycemic control to cardiorenal risk control in diabetes places SGLT2is high on the list of pharmacologic agents to be used early in treatment

Although current evidence does not demonstrate a strong causal link, clinical judgment still matters

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These drugs are typically prescribed to adults and now teens, who are obese (BMI above 30)

While some people may wonder if combining medications could lead to greater weight loss, there are currently no clinical studies or FDA recommendations supporting the use of Wegovy and Contrave together

[1] [7] Cases were very infrequent in clinical trials, and real-world post-marketing data have been consistent with these findings