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doi: 10.2147/POR.S471476

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Unlike native GLP-1, which has a half-life of only 1-2 minutes due to rapid enzymatic cleavage, the unique lipidization of the Semaglutide Peptide allows it to strongly bind to serum albumin, facilitating a substantially prolonged half-life for extended observational studies

All analyses were operated in data-dependent mode, where the most intense peptides were automatically selected for fragmentation by high-energy collision-induced dissociation

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