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Stimulation of Lcells with the designer drug clozapine N oxide (CNO) improved glucose tolerance and significantly reduced food intake and body weight, although the latter effects may have been mediated by peptide YY (PYY), which is cosecreted with GLP1 from Lcells
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Hyperglycemia, insulin resistance, impaired pancreatic -cell function, and risk of pancreatic cancer

Its smart to avoid hard workouts immediately after eating because these tend to amplify nausea

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Many patients report that semaglutide makes greasy or high-sugar foods genuinely unappetizing, creating a natural shift toward nutrient-dense eating
