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Administration of metformin increases the abundance of SCFAs-producing microbiota (described previously, see Chapter 4.3), thereby increasing the production of SCFAs

Higher doses produce more pronounced gastric emptying delays, which produce more fermentation, which produces more gas, which produces more burping

Only about 4% of people in studies needed to stop the medication because of their GI symptoms, which suggests that with the right support, relief is possible

If youre not sure what to sip, or youve had days where thirst cues feel muted on GLP-1, start with the basics in our GLP-1 hydration guide and keep this list simple: Water in small, steady amounts (set it next to you and take frequent sips) Electrolyte drink if tolerated (especially if you feel weak or youve had multiple watery stools) Salty broth (often easier than sweet drinks) What not to do, if you can help it: Dont chug huge amounts at once (it can backfire fast) Go easy on caffeine if it worsens urgency Skip alcohol if your stomach is already irritated Avoid very sugary drinks if they make symptoms worse MedlinePlus explains that diarrhea treatment focuses on replacing fluids and electrolytes to help prevent dehydration

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