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One rat treated with exenatide died of pancreatic necrosis, and other animals had findings of acinar-to-ductal metaplasia and foci of ductal hyperplasia, which were interpreted as premalignant changes 6,7

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Obesity substantially increases the risk of contracting more than 200 diseases, such as arterial hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, cerebral vasculopathy, gallbladder lithiasis, arthropathy, sleep apnea syndrome, and neoplasms [1, 2]

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