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These outcomes not only improve patient health and quality of life but also increase physician confidence in prescribing GLP-1 therapies

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Both TNF- and IL-6 can reduce the expression of intracellular glucose transporter 4 (GLUT4), inhibit normal phosphorylation of insulin receptors and insulin receptor substrate 1 (IRS-1), block GLUT4 translocation, and lead to IR.18,19 IL-1 can lead to the abnormal expression and translocation of GLUT4 in ovarian granulosa cells by reducing insulin-induced AKT phosphorylation.20,21 Therefore, improving the chronic low-grade inflammation of the ovary may provide new strategies for the treatment of PCOS

Treatment focuses on managing symptoms and addressing the underlying metabolic and hormonal imbalances in the body

Our analysis indicated that DPP-4i treatment has a mild anti-hypertensive effect as a monotherapy and causes a significant reduction in BP when used in combined treatments

underlying conditions remain the main driver
