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Heres what they do: Help your body release insulin when your blood sugar is high Reduce another hormone called glucagon that usually increases blood sugar Slow down digestion , so you feel full for longer Send signals to your brain to curb hunger and reduce cravings This multi-action approach is what makes GLP-1 drugs helpful in both type 2 diabetes and weight management If Our Body Already Makes GLP-1, Why Take It From Outside

These differences affect patient care in important ways

The addition of GIP agonism in tirzepatide enhances first- and second-phase insulin secretion, reduces fasting and postprandial glucagon concentrations and therefore reduces postprandial glucose levels further

The prize is administered by Feinberg through the Simpson Querrey Institute for Epigenetics

CVOT, cardiovascular outcome trial