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In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide.

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Greater knowledge of the mechanisms of fat fuel partitioning that underlie the metabolic and behavioral actions of GLP-1RAs could also provide a roadmap for the development of new or adjunctive pharmacological or other strategies for treating obesity and associated metabolic diseases," they conclude

90% (n=225) of patients were female, with an average age of 41.312 years

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However, treatment decisions should also consider tolerability, long-term adherence, cost, weight regain after discontinuation, and patient preferences