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In one study, individuals who took Wegovy lost an average of 15% of their body weight, compared to only 2.4% for those who took a placebo

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and modifying post-treatment trajectories, with scenarios assuming reversion to natural progression without the benefit of diet and exercise, as well as accelerated catch-up with treatment effects fading completely within 1 year

Researchers are studying whether these effects influence the gut microbiome, intestinal barrier, and overall gastrointestinal health, but the available evidence remains limited

Injectable GLP-1 agonists like Ozempic (injectable) have the most consistent evidence for large weight loss