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Both have their place

UCP1 is expressed in brown adipose tissue (BAT), UCP2 is expressed in a number of tissues such as the intestines and adipose tissue, while UCP3 is expressed in skeletal and heart muscle

caution in severe gastrointestinal disease
Inflammation in obesity-related HFpEF: the STEPHFpEF program

People with specific GIPR variants experience more pronounced insulin and appetite responses to mixed meals, which indirectly influences GLP-1 secretion patterns during fasting periods
