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The results of cardiovascular and kidney outcomes trials involving sodiumglucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, including assessment of subgroups, inform broader recommendations for cardiorenal protection in people with diabetes at high risk of cardiorenal disease

RCTs using dedicated retinal imaging are required to determine the causal relationship with these therapies

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However, further scientific studies are still underway to maximize the benefits of GLP-1RAs and to discover additional roles in improving health benefits

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion