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Nausea and diarrhea were the most common side effects which were transient and improved with time, with less than 5% of the patients in the treatment group discontinuing treatment from gastrointestinal side effects

If you have ulcerative colitis and are considering GLP-1 therapy, integrating genetic predisposition data with your baseline disease markers and provider expertise can help ensure safer, more personalized treatment planning

Effectiveness Both medicines have been shown in clinical trials to be highly effective at helping people lose weight, with Mounjaro (tirzepatide) helping people lose 22.5% of their starting weight on average, and Ozempic/Wegovy (semaglutide) helping people lose around 21% of starting weight

Impact on AMD A 2025 retrospective published in JAMA Ophthalmology looked at the incidence of developing wet age-related macular degeneration (AMD) three years after initiation of treatment with GLP-1 drugs