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Although glycemic control with intensive therapies with insulin has reduced the incidence of microvascular and macrovascular complications, most people with T1DM1 glycemic control

This was the first head-to-head comparison, published in the New England Journal of Medicine

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If you feel more tired after a dose increase this is normal, but if tiredness is beginning to interfere with your daily routine, then it might be worth reducing your dose again

In addition, LEADER, SUSTAIN-6, HARMONY, PIONEER 6, REWIND, and AMPLITUDE-O found that GLP-1RAs had cardioprotective effects independent of their ability to lower blood glucose levels

If you notice cold sensitivity coinciding with other symptoms like fatigue or hair loss, ask your provider to check thyroid function and micronutrient levels