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The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]

This layered approachstarting with appropriate dosing, monitoring thyroid labs closely, and refining therapy based on genetic datamaximizes safety and efficacy for complex cases

This literature review was conducted following the PICO Framework, with details available in Supplementary material 1

No funding was received for this research

Liraglutide is a GLP-1 receptor agonist sold by Novo Nordisk under the brand names Victoza and Saxenda