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Tirzepatide further slows gastric emptying, which can exacerbate existing gastroparesis and make blood sugar control more erratic
Effects of glucagon-like peptide-1 receptor agonists on upper gastrointestinal endoscopy: a meta-analysis

[DOI] [PubMed] [Google Scholar] 59.Hu Y, Liu J, Wang G, Xu Y

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32,47 The key factors increasing cell death include endoplasmic reticulum stress (leading to accumulation of unfolded and misfolded proteins within this key subcellular compartment critical in the biosynthesis of secretory and structural proteins as well as steroids, cholesterol, and other lipids), oxidative stress, mitochondrial dysfunction, inflammatory stress, and inclusions of aggregated peptides that reside within a similar intracellular milieu as do neuronal cells in PD
