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Co-administration with insulin or sulfonylureas significantly increases the risk of hypoglycemia

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However, central administration of LEAP2 reduces binge-like intake of a HFD, an effect not observed with central ghrelin administration or with pharmacological blockade of GHSR using the antagonists [D-Lys3]-GHRP-6 and JMV2959

Long-term effects of Roux-en-Y gastric bypass surgery on plasma glucagon-like-peptide-1 and islet function in morbid obese subjects