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Acute kidney injury has occurred, often in the context of severe dehydration from gastrointestinal side effects, emphasising the importance of maintaining adequate hydration
Exposures involving these agents in addition to sulfonylureas or insulin may warrant closer monitoring

In 2023, Sterigenics agreed to a $408 million settlement over similar ethylene oxide exposure claims in Illinois, Georgia, and Michigan

These side effects are more common when starting treatment or after increasing the dose

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Changes in body composition may occur during treatment