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Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity
Frequently Asked Questions Is GLP-1 Up safe
Baseline metabolic status also matters
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Immunology 151(4):363374 Jensen AB, Srensen TI, Pedersen O, Jess T, Brunak S, Allin KH (2018) Increase in clinically recorded type 2 diabetes after colectomy
Many patients find their alcohol tolerance decreases significantly on GLP-1 therapy
