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60 Although modest at the individual level, a 5 mm Hg SBP reduction has been associated with about a 10% lower risk of major cardiovascular events, including 13% reductions in both stroke and heart failure, 8% in ischemic heart disease, and 5% in cardiovascular death, making these effects important at a population level

The retatrutide 12mg cohort did not demonstrate this plateau pattern within the 48-week observation window

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