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Parallel randomized studies in Hashimoto thyroiditis and Graves disease should pre-specify metabolic co-endpoints (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Magnetic Resonance Imaging-Proton Density Fat Fraction (MRI-PDFF) for liver fat) to test the immunometabolic hypothesis suggested by observational signals and secondary analyses [32,60]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Buttgereit F., Da Silva J.A., Boers M., Burmester G.R., Cutolo M., Jacobs J., Kirwan J., Khler L., van Riel P.L., Vischer T., et al

The term had circulated in patient communities and across TikTok for years, but it reached a mass audience in 2024, when Oprah Winfrey devoted a primetime special, "Shame, Blame and the Weight Loss Revolution," to weight-loss medications and spoke candidly about how they quieted her own food noise