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[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al
Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

Other large cardiovascular outcomes trials are being conducted to evaluate the cardiovascular safety of exenatide QW (EXenatide Study of Cardiovascular Event Lowering [EXSCEL

Table of Contents Understanding the Oral GLP1 Opportunity Reframing the Market: From Weight Loss to WholePerson Outcomes Messaging that Matters: Clarity, Context, and Credibility Channel Choices in a Multiformat Environment Addressing Access, Affordability, and Health Inequities Staying Honest About Safety and Expectations Measuring Success in a Complex Therapeutic Landscape FAQs Understanding the Oral GLP1 Opportunity The arrival of oral GLP1 therapies is transforming treatment pathways

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DOI: 10.1111/bph.15677,