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Common side effects include nausea, vomiting, diarrhea, constipation, and reduced appetitetypically transient but occasionally severe enough to require dose reduction or discontinuation

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Common symptoms of irritation at the injection site include: Severe pain Blisters An open wound Swelling Dark scabs While these symptoms may seem initially harmless, they can worsen over time and even require surgery

however, using genetic approaches to target specific neurons, a recent study challenges that idea 32

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In this study, unlike previous studies using non-diabetic animals, we demonstrated using diabetic model rats and confocal laser scanning microscopy that the GLP-1/GLP-1R complex was located in the endosome of diabetic islets