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Mazdutide and several other triple and quadruple agonists are in earlier development phases

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[117] demonstrated that dapagliflozin provides direct cardiac protection by suppressing the NHE1/mitogen-activated protein kinase/activator protein-1 pathway-mediated inflammatory response in cardiomyocytes, reducing proinflammatory macrophage infiltration in the cardiac tissue of HF mice

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Subscribing to journals, attending conferences, and reviewing clinical guidelines will help integrate new evidence into practice responsibly
