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According to a recent meta-analysis of the SURPASS program, tirzepatide showed a numerical but not statistically significant reduction of MACE vs

However, in patients over 65, those with a history of prediabetes/diabetes, anyone with a cardiovascular disease, and anyone who has been severely overweight should expect to stay on medication forever due to the significant reduction in disability and death

The NO level of each group was normalized to its total protein

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