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GLP-1 patches promise convenience, but current evidence shows injected GLP-1 medications like semaglutide deliver faster, more reliable results for sustainable weight loss and metabolic health

Common AEs were nausea (23%), vomiting (6%), diarrhea (6%), constipation (10%), headache (6%), fatigue (8%), abdominal pain (2%), and abdominal bloating (2%)

The authors found that the number of GLP-1 expressing cells is consistently reduced at the site of active disease in both mouse models of intestinal inflammation and in CD patients, as confirmed by the single-cell RNA sequencing data