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Description
DPP-4i: dipeptidyl peptidase-4 inhibitor
Sinoatrial node chronotropy direct Gs/cAMP signaling via GLP-1R at the hearts pacemaker, running through the pacemaker cells sarcoplasmic-reticulum calcium clock (phospholamban Ser16 and ryanodine-receptor phosphorylation), not the funny current
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Therefore, GLP-1RAs and GIP-RAs hold promise to be potential treatments for a wide variety of diseases
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