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The progression of semaglutide from a metabolic drug to a potential neuroprotective agent is ongoing, but its future role in neurology will likely focus on the prevention of neurodegeneration rather than the treatment of established diseases

14 GLP-1 (736) NH 2 , exenatide (128) and GIP (130), all have two polar residues starting from position 27: GLP-1 has Lys 28 and Arg 30 , exenatide has Lys 27 and Asn 28 , and GIP has Gln 29 and Lys 30

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2018;378(25):e34