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ICH Concept Paper E9 (R1): Addendum to Statistical Principles for Clinical Trials on Choosing Appropriate Estimands and Defining Sensitivity Analyses in Clinical Trials, 2014

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Clear documentation of medical necessity and patient education about realistic weight loss expectations strengthens prescribing decisions

2024/05/01 2024 doi: 10.1038/s41366-024-01527-1

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In overweight adults with high blood pressure, diabetes, or high cholesterol, semaglutide injection (Wegovy) is used in conjunction with a low-calorie, low-fat diet and exercise program to lose weight
