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Continuous flow SPPS, demonstrated commercially by companies including Vapourtec using Fast-Flow SPPS technology, enables coupling reactions to proceed in a continuous flowing regime rather than in discrete batch cycles, significantly reducing synthesis time, improving reagent efficiency, and delivering peptides with improved purity profiles by minimising the exposure window for side reactions

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Additionally, liraglutide shifted polarized macrophage phenotype in vitro from the pro-inflammatory M1 phenotype to the M2 anti-inflammatory phenotype

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