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doi: 10.3389/fphar.2026.1791206 Received 19 January 2026 Revised 13 April 2026 Accepted 14 April 2026 Published 01 May 2026 Volume 17 - 2026 Edited by Kabirullah Lutfy, Western University of Health Sciences, United States Reviewed by Marsida Kallupi, University of California, San Diego, United States Christina Merritt, University of Texas Medical Branch at Galveston, United States Updates Copyright 2026 Hrickova, Demirci, Amchova and Ruda-Kucerova

GLP-1 receptor agonists mimic the action of a natural hormone called glucagon-like peptide-1 (GLP-1), which is released in response to eating

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72 , 73 A large international cohort study across six population-based databases compared nearly 100,000 GLP-1 RA users to over 2.4 million dipeptidyl peptidase-4 (DPP-4) inhibitor users and found no evidence of increased thyroid cancer risk (pooled weighted HR: 0.81, 95% CI 0.59, 1.12)