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The antagonist did not affect the birth weight of pups of sham-operated mice

Exenatide immediate-release (Byetta): Initiation involves a 5 mcg dose administered subcutaneously twice daily, which can be increased to 10 mcg twice daily after a month if required

This is further supported by the near-complete absence of cardiac Glp1r mRNA in Glp1r Tie2/ mice (57), suggesting that mouse cardiac Glp1r expression is primarily contributed by endothelial cells and/or immune cells

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Beyond those concerns, experts point to several other potential downsides: Limited evidence for people without obesity or related conditions

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