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[published online November 9, 2025]
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Given that obesity is a common comorbidity of inflammatory bowel disease (85), further research is needed to understand the significance of the GLP-1R downregulation during inflammatory bowel disease and how GLP-1 medicines interact with inflammatory bowel disease through both metabolic improvements and direct antiinflammatory actions on the intestine
In 2022, Eli Lilly launched Tirzepatide, a novel dual GLP-1RA/GIPR agonist administered once weekly by subcutaneous injection that activates both GLP-1 and GIP receptors
doi: 10.1056/NEJMsr1606602 [DOI] [PMC free article] [PubMed] [Google Scholar] 7
doi: 10.1002/jcph.396
