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Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial

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Preliminary data point toward beneficial effects of GIP agonism, as reported in findings from the SURPASS program that tirzepatide reduced UACR and slowed down eGFR declined in comparison with both placebo (53) and comparator drugs including insulin glargine (74, 75)

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Of these, two studies ( N = 16 and N = 46, respectively) observed a positive association between the use of exenatide, liraglutide or dulaglutide and weight loss as well as HbA1c at 16 weeks 149 and 1 year 150 , while for the smaller one ( N = 7) this association was not significant 148

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Understanding whether GLP-1 therapy directly affects stool colour, when changes warrant medical attention, and how dietary modifications influence bowel appearance helps patients distinguish between expected effects and potential complications

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Glucagon-like peptide-1 receptor agonist liraglutide ameliorates the development of periodontitis

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doi: 10.1900/RDS.2010.7.15

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