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As GLP-1R agonists mediate their appetite-reducing effects within the central nervous system, the trafficking phenotype of exendin-phe1 could result in reduced brain penetration, mitigating against presumed advantageous effects on neuronal GLP-1R desensitization
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According to this study, semaglutide use was associated with reductions in muscle mass and ASMI
And its anabolic-related genes include fibroblast growth factor-21 (FGF21), SREBP-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC-a), liver X receptor (LXR), suppressor of cytokine signaling-3 (SOCS-3), etc
