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Common Side Effects (Frequently Reported) Based on clinical trial safety data, the most commonly reported side effects include: Gastrointestinal effects: Nausea (reported by approximately 20-40% of users in clinical trials, depending on dose) Diarrhea Vomiting Constipation Abdominal pain or bloating Indigestion or acid reflux Other common effects: Fatigue or low energy Headache Dizziness Decreased appetite (this is often the intended effect but can become uncomfortable) Typical pattern: According to clinical data, gastrointestinal side effects are generally most pronounced during dose escalation periods and often improve as your body adjusts to the medication

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Tachycardia: Fast Heart Rate Quick Facts The normal average resting heart rate is 60-100 beats per minute

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Hormonal adaptation also plays a role in weight regain

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We compared GLP-1RAs with SGLT2 inhibitors and metformin and found that GLP-1RAs significantly reduced the incidence of major CVEs and mortality rate compared with metformin and second- or third-line glucose-lowering medications

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This effectiveness gap is crucial when weighing Mounjaro vs Trulicity for blood sugar management

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