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74 In AD, the ELAD trial found that liraglutide did not significantly affect brain glucose metabolism, although exploratory analyses suggested some benefits on cognitive function and brain atrophy

Caregiver administration is acceptable if the patient cannot self-inject due to physical limitations, tremor, or anxiety

Nogueiras et al., 2023)

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Some weight regain is possible during a month off tirzepatide as the medication's appetite-suppressing effects diminish, though substantial regain typically occurs over longer periods depending on diet, activity level, and individual metabolism