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While rare, there is a possibility of experiencing serious side effects, including allergic reactions

Sulfur burps are a side effect of how semaglutide slows digestion, but they're not an indicator of weight loss effectiveness

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and (ii) incidence of stroke, fatal, and nonfatal stroke in T2DM-patients treated with GLP-1 or GIP/GLP-1 RAs (vs placebo)

Expert Rev Clin Immunol (2021) 17:10537

That's the sweet spot for muscle preservation without overwhelming your system when your energy and recovery might be lower than usual
