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If GLP-1 and GIP have beneficial effects on blood glucose regulation, and if they are broken down by the enzyme DPP-4, then one logical pharmacological strategy is to inhibit DPP-4

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They also had a 4 percent higher risk of cardiovascular issues than those continually on a sulfonylurea

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The week-by-week results were particularly telling

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"The discovery and development of liraglutide and semaglutide." Frontiers in Endocrinology , 10, 155

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Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus

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