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32 The primary outcome for the trial was the first occurrence of a major adverse cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)

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The most direct evidence so far comes from a 2025 study out of UCLA, published in ACR Open Rheumatology

G Protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes, and oligodendrocytes, fluctuates during the estrous cycle, and is sexually dimorphic

Watch for signs of pancreatitis (severe stomach pain), gallbladder issues (upper right abdominal pain), dehydration from persistent vomiting or diarrhea, or allergic reactions (swelling, difficulty breathing)