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She took up running half-marathons, but at that weight, it was painful

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When Side Effects Push Users Away Additionally, people who had previously used gastrointestinal medicationswhich may indicate they are more vulnerable to the common adverse gastrointestinal side-effects reported by GLP1-RA users, such as nausea, vomiting, diarrheawere 9% more likely to discontinue semaglutide within the first year

Drucker provides this illustration of the mechanism: Scientists still arent quite sure how these drugs effectively moderate every system that they touch

Overall tolerability of the treatment was good, with the most common side effect being nausea, particularly during treatment initiation or dose adjustments, while diarrhea was reported by 5% of patients, which was dose-dependent and easily managed

One individual shared how, after beginning treatment with semaglutide, their blood pressure normalized, leading to a reduction in their medication