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Some sub-analyses of large clinical trials suggest that GLP-1RA and sodium-glucose cotransporter 2 inhibitor combination therapy may provide more significant reductions in heart failure hospitalization and renal composite events than each alone

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GLP-1RAs show modest SBP reductions (1.85.1 mmHg) and minimal DBP effects (~0.5 mmHg), though tirzepatide shows greater efficacy (~10.6 mmHg) in select populations