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The therapeutic class is experiencing unprecedented demand as prescriber awareness of pleiotropic benefits, including kidney disease event reduction and major adverse cardiovascular event reduction, reshapes treatment algorithms

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Because retatrutide acts on three receptors, some researchers call it a triple agonist. This design may explain why trial results gained so much attention

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The TAME (Targeting Aging with Metformin) trial is investigating metformin specifically for anti-aging purposes

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