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Insulin Glargine in Combination with Metformin and Glimepiride in T2D Patients)94), 0.75- and 1.5-mg doses of once-weekly dulaglutide were compared with a 1.5-mg dose of insulin glargine, titrated to target a fasting blood glucose level around 100 mg/dL, based on metformin treatment

T.A.is supported by an NIHR Senior Clinical and Practitioner Award and reports institutional grants or contracts from Nova Pharmaceuticals, Astra-Zeneca

Previous studies have demonstrated that the cAMP/p-AMPK/p-ACC and insulin-sensitizing pathways are pivotal to GLP-1s beneficial effects on hepatic lipid metabolism