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In order to benefit from the bicarbonate, the patient should have enough time to blow off additional CO 2 prior to intubation

Many patients experience: Delayed gastric emptying Severe nausea Bloating Early satiety Semaglutides mechanism includes: Slowing gastric emptying Reducing GI motility Increasing satiety via vagal pathways Clinical observations also increasingly report: Worsening nausea Increased bloating Vomiting Gastroparesis-like symptoms So, while potentially beneficial in metabolic disease or overweight patients, in individuals already predisposed to gastrointestinal dysmotility, autonomic dysfunction, and vagal dysregulation, these effects can be extremely problematic and counterproductive

Certain conditions make semaglutide unsuitable

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While the largest potential absolute benefit by race/ethnicity was observed in non-Hispanic White individuals, with 86,010 MACE (~ 14%), 21,123 cardiovascular deaths (~ 6%), 64,602 nonfatal myocardial infarctions (~ 25%), and 18,864 nonfatal strokes (~ 11%) prevented

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