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Experiments were repeated three times and error bars represent s.e.m

Similarly, the substudy of the obesity phase 2 trial showed clear promise for retatrutide in the treatment of MASLD [47], and through its GCG receptor agonism, retatrutide may offer benefits beyond WL, through weight-independent metabolic effects at the liver [40]

27 Tirzepatide (Figure 1H) was designed to bind GLP-1/GIP receptors by modifying the native amino acid sequence of GIP

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These differences suggest that activation of central GLP1 neurons within the nucleus tractus solitarius and subsequent downstream GLP1 receptor containing circuits may provide a useful tool for controlling food intake