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Avoid sudden, large drops in glucose by aiming for steady improvements

Its important for patients to follow their healthcare providers dosing recommendations and discuss any persistent side effects, as there are often adjustments or supportive treatments that can help manage these symptoms

Conversely, sacubitril/valsartan has been shown to increase PRA, ANG I and ANG II levels in a canine model of RAAS activation

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Among the most common GI side effects, namely nausea, vomiting, diarrhoea and constipation, nausea appears systematically as the most frequent event in all clinical trials